معلومات المساق

Objectives:
Organometallic reagents and catalysts play a pivotal role in organic synthesis. This course will focus on the fundamental
principles of organometallic chemistry. It will then highlight the use of transition metal catalysts in organic synthesis
with reference to the most recent literature. This includes fundamental aspects of asymmetric catalysis illustrated by
recent achievements.

Contents:
1. Basics and fundamental principles
2. Mechanisms
3. Cross-coupling
4. Heck reactions
5. Olefin metathesis
6. Hydrogenation
7. Asymmetric hydrogenation
8. CO insertion chemistry
9. Cycloadditions
10. Wacker-type reactions
11. π-allyl chemistry
12. C-H activation

Documentation and bibliography:
L.S. Hegedus (1999). Transition Metals in the Synthesis of Complex Molecules; 2nd edition. University Science, Mill
Valley, CA.
R.H. Crabtree (2000). The Organometallic Chemistry of the Transition Metals; 3rd edition. Wiley, New York.
J.F. Hartwig (2010). Organotransition Metal Chemistry. University Science Books.
E.N. Jacobsen, A. Pfaltz, H. Yamamoto, Editors (1999). Comprehensive Asymmetric Catalysis. Springer, New York.